| PRODUCT NAME: |
AIA-PACK RBC FOLATE |
| INTENDED USE: |
AIA-PACK RBC FOLATE is designed for IN-VITRO DIAGNOSTIC USE for the quantitative measurement of red blood cell folate (RBC folate) in whole blood (heparin or EDTA) on Tosoh AIA immunoassay analyzers. |
| SUMMARY AND EXPLANATION OF TEST: |
Folate is an essential dietary requirement and may be found as polyglutamate forms in a variety of leafy plants and animal organ tissues. Folate is converted to monoglutamates and absorbed in the jejunal mucosa of the small intestine. After enterocyte conversion, folic acid is released into portal circulation. The majority of folic acid circulates in human serum primarily as N5-methyltetrahydrofolate. Deficiencies of either folate or vitamin B12 may result in megaloblastic anemia and neuropathy. Folate deficiency may be produced by several factors including inadequate dietary intake, intestinal malabsorption, pregnancy, alcoholism and a variety of drugs, including oral contraceptives and anticonvulsants. Although serum folate offers a reliable test, it fluctuates resulting from dietary changes. Erythrocyte folate or folate in red blood cells, however, does not become depleted as quickly as serum and is much more concentrated than that in serum. Erythrocyte folate concentration correlates well with other indexes of folate deficiency such as bone-marrow cell morphology and hematological changes. Therefore erythrocyte folate concentration is considered as a reliable indicator of folate status. |
| TECHNICAL SPECIFICATIONS: |
|
Method: |
Enzyme Immunoassay (EIA) |
| Principle: |
Competitive enzyme immunoassay |
| Calibrators: |
0, 3.25, 6.50, 13.50, 25.0, 44.0 ng/mL |
| Assay sample: |
Whole blood |
| Assay range: |
0.5 - 24 ng/mL |
| Storage: |
2 - 8 ºC |
| Kit Contents: |
AIA-PACK RBC FOLATE |
| Consumables: |
AIA-PACK SUBSTRATE SET II
AIA-PACK RBC FOLATE CALIBRATOR SET
AIA-PACK RBC FOLATE SAMPLE DILUTING SOLUTION
AIA-PACK RBC FOLATE PRETREATMENT SET
AIA-PACK RBC FOLATE HEMOLYZING REAGENT SET
AIA-PACK WASH CONCENTRATE
AIA-PACK DILUENT CONCENTRATE
AIA-PACK DETECTOR STANDARDIZATION TEST CUP
AIA-PACK SAMPLE TREATMENT CUP
SAMPLE CUPS |
*Please refer to the product Instruction-For-Use (IFU) for complete details.